Sabrina Maisel’s presentation, on behalf of Stemson Therapeutics, introduced an innovative hair restoration approach using induced pluripotent stem cell (iPSC)-derived Folliculogenic Organoids. Addressing the broad and often emotionally distressing issue of hair loss - which affects tens of millions globally - the company’s therapy targets not only androgenetic alopecia but also hair loss from trauma, chemotherapy, and autoimmune disorders. Existing treatments like Rogaine and Propecia only preserve existing hair follicles, and hair transplantation is often unsuitable for women and those with widespread hair thinning. Stemson aims to create entirely new hair follicles, a capability current treatments lack.
The company’s process begins with isolating blood samples and generating iPSCs, which are then differentiated into two key cell types critical for hair follicle development: dermal papilla and epithelial bulge stem cells. These cells are combined to form folliculogenic organoids, which can be mass-produced and are compatible with robotic transplant systems already used in cosmetic surgery.
Stemson has developed a proprietary four-stage, scalable system for cell differentiation and follicle formation. They incorporate high-throughput screening and computational analysis to refine cell identity and function, including using data from large drug screening databases to enhance the performance of their organoids with small molecules. To overcome handling challenges and ensure transplant viability, they developed a hydrogel-based scaffold system allowing orientation and survival of hair organoids in vivo.
Transplantation trials in mouse models demonstrated successful follicle integration and hair growth through human skin xenografts. Future directions include clinical applications in burn victims and others with non-regenerative scalp conditions. While questions remain - such as hair colour retention and integration in damaged skin - early data is promising. The team is also considering advanced phases for aesthetic customization like hair texture and pigmentation.
Stemson’s approach represents a breakthrough in regenerative dermatology, offering a regenerative, personalized therapy that could replace lost follicles and restore hair growth in a broader range of patients than current solutions allow.
