Invite is a public-private partnership between Bayer, Technical University Dortmund, and the Heinrich Heine University in Düsseldorf. Invite’s aim is to drive innovative production technologies and realise them as the approaches of the future through collaboration with academia and industry. Their focus spans several fields including automation, robotics, formulation technology, and in sustainability research.
The team leads the Drug Delivery Innovation Center (DDiC), an open consortium between pharmaceutical companies, equipment manufacturers, and academia. The centre promotes cross-industry collaboration, aiming to accelerate the application of academic research in the pharmaceutical industry.
This presentation highlighted a PhD project which evaluated the solubility, colloidal stability, and conformational stability of high concentrated protein formulations. The study used modelling approaches to predict optimal excipient mixtures, with significant findings on the beneficial water conditions and the impact of excipients on stability.
Results from this project identified the beneficial water conditions with respect to solubility, finding arginine and histidine being the most suitable amino acids independent of the antibody. With respect to conformational stability, they found that negative influences of single excipients can be compensated by using mixtures. Furthermore, looking at colloidal stability, they saw increasing charge and side chain length in the amino acids of the protein.
The second half of the presentation focused on a project called MoBiDiK (Modular Bioproduction Disposable Continuous). This project aimed to enhance the robustness and yield of manufacturing processes for biologics using modular and continuous production systems. The project successfully demonstrated a continuous production setup with significant output and robustness, confirming the advantages of single-use systems in modular approaches
