We present the first published DNA‑encoded library selection against an ion channel, enabled by detergent‑free Salipro® lipid nanoparticles. Using PANX1, we identify functional small‑molecule modulators validated by SPR, cryo‑EM, and electrophysiology, demonstrating a robust DEL workflow for challenging membrane proteins.
Jens Frauenfeld, Chief Executive Officer, Salipro Biotech
