Market Insight Drug Development |

SPOT On – Boosting Targeted Lipid Nanoparticles Via SiteSpecific Conjugation Strategy

Peter Bitsch

Peter Bitsch

Conjugation Specialist, Next Gen Drug Delivery

Discovery Park Ltd

12 August, 2026
Watch time: 18 Minutes

Highlights

Takeaways

Next Gen Drug Delivery at MERCK KGaA developed a unique system for activation and subsequent immobilization of binders at LNP surface for cell specific oligonucleotide delivery. This Site-specific Protein Optimization for Targeting (SPOT^TM) technology allows for the generation of LNPs with outstanding targeting and transfection efficiency in vitro and in vivo.

Peter Bitsch, Conjugation Specialist, Next Gen Drug Delivery, Merck

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