- Trifluoromethyl groups have historically been key functional groups to optimize compound series in drug discovery
- However, their persistence in the environment has raised concerns about their impact on sustainability
- We show how we can finetune the stability of trifluoromethyl groups to be stable enough for medicinal chemistry while not persisting prolonged time in the environment
Stefan Schiesser, Director of Medicinal Chemistry, AstraZeneca
