Chemical biology connects biological insight to therapeutic opportunity. This talk highlights how chemical probes and targeted protein degradation, including PROTACs, interrogate protein function in cells to support target discovery and validation. Examples show how orthogonal perturbations reveal mechanisms, clarify causality, and uncover biology beyond inhibition, informing targets, leads, and biomarkers.
Kilian Huber, Associate Professor, Senior Group Leader Chemical Biology & Chemical Probes, University of Oxford
